Alli Review: Can This Weight Loss Pill Really Help You Lose Weight?

Ingredient Analysis

Supplement Facts

Alli claims to be a weight loss supplement that helps people lose weight by stopping the body from absorbing fat. But is this really true?

To evaluate the efficacy of Alli, we examined its ingredients. Let's take a close look at the active and inactive ingredients.

• The active ingredient is Orlistat 60 mg
• The inactive ingredients are Microcrystalline Cellulose, gelatin, iron-oxide, povidone, FD&C Blue No. 2, Sodium Lauryl Sulfate, Sodium Starch Glycolate, talc and Titanium Dioxide.

Ingredient analysis - Fat Absorption Inhibitor

The primary ingredient in Alli is marketed as a fat-blocking agent (which is effective if your goal is to reduce fat absorption). However, this approach may not be the most efficient if you’re looking for a supplement that actively boosts metabolism or burns fat. Here’s what we discovered when we dug deeper into this ingredient.

Orlistat (60 mg) is the main ingredient, and it works by blocking enzymes (lipases) that break down fat from food.

According to Dr. Lisa Thompson, Clinical Nutritionist Orlistat works by blocking the enzyme responsible for breaking down fat, which can help reduce fat absorption. However, it’s important to note that while it can support weight loss, its effects are modest and best achieved when combined with a low-fat diet.

Unlike thermogenic supplements that boost calorie burning, Alli only stops some fat from being digested. This helps reduce calorie intake but doesn’t help burn stored fat for energy.

Research from the Cochrane Library mentioned an Orlistat study where it was shown that Orlistat helps the body get rid of about 30% of the fat from food by blocking an enzyme that breaks down fat. This can reduce calorie intake and support weight loss.

We found a Randomized Placebo-Controlled Trial that tested orlistat (120 mg, three times daily) on 743 obese people over two years. In the first year, those taking orlistat lost more weight than those on a placebo (10.3 kg vs. 6.1 kg). In the second year, those who continued orlistat regained less weight, while those who stopped regained more.

This study also showed that orlistat improved cholesterol, blood sugar, and insulin levels but caused more digestive issues. The study concluded that orlistat helps with weight loss and maintenance, but long-term use needs monitoring due to potential side effects.

Now, while this study looks good on paper, it begins to lose its wonder when you truly look at it.

First, no one wants to wait 2 years to lose weight. And 10.3 kg is only about 22 pounds, which means people who used 360 mg of orlistat per day only lost 1.8 pounds a month. That’s hardly significant.

Not to mention that participants of the study were on a calorie deficit diet. Also, Alli only contains 60 mg of orlistat to be used for 3 times a day. This is half the daily dose used in the study and may not help you lose weight.

Also, Orlistat is a pharmaceutical drug and not a natural supplement like KetoFuse. Unlike Orlistat, which forces fat excretion through enzyme blocking, KetoFuse uses natural ingredients to support metabolism and fat burning without interfering with digestion. This makes KetoFuse a more natural and safer option for weight management.

We disapprove of this ingredient for weight loss.

We Tried Alli

Alli

After I heard about Alli’s claims as an FDA-approved weight loss aid, I decided to give it a try. Adding it into my routine was simple, as the capsules were easy to take with meals, and there was no noticeable aftertaste.

During the first few weeks, I noticed some changes. My digestion felt different, likely due to the way Alli blocks fat absorption. However, I quickly realized that sticking to a low-fat diet was important—on days when I consumed too much fat, I experienced some unpleasant digestive side effects.

By the end of the second month, I had lost only a little weight. The results weren’t as dramatic as I had hoped. While Alli did seem to help reduce fat absorption, it didn’t curb my appetite or boost my energy levels. The requirement to closely monitor fat intake also made the experience somewhat inconvenient.

In conclusion, Alli is easy to use and may help with gradual weight loss, but it’s not a magic pill—you still need to follow a strict diet for it to be effective. Based on my experience, I wouldn’t personally recommend it as the best standalone weight loss solution. I won’t be repurchasing it, and I’d rate it 5/10.

Side Effects & Safety of Alli

While Alli is generally considered safe for most individuals, it does come with potential side effects, particularly related to its fat-blocking mechanism. Since Orlistat prevents fat absorption, unabsorbed fat is excreted, which can lead to digestive discomfort. Common side effects reported by users include:

• Oily stools
• Frequent or urgent bowel movements
• Gas with discharge
• Abdominal cramping

These effects are more likely to occur if too much fat is consumed while taking Alli. However, they often decrease over time as the body adjusts to the medication.

Alli is FDA-approved, non-GMO and contains no stimulants, which makes it different from many other weight loss supplements. Individuals with digestive disorders or liver disease, or those taking certain medications should consult a healthcare professional before using Alli to ensure it is safe for their specific health needs.

During our research on Alli, we found a YouTube video by Glozine, a trusted source for health-related insights.

Real Customer Reviews

Alli is not currently accredited by the Better Business Bureau (BBB) and TrustPilot.

Alli is sold under different brands on Amazon and has been reviewed 25,316 times with an average rating of 4.1 out of 5 stars.

A top positive review is from a verified purchaser and comes from a user named Makayla Hanik, who gave the product a 5/5 rating:

They definitely work. It's been a week now. I have taken these pills every time I eat, and the first few days nothing happened. I ate my first greasy food today ( pizza ) and Chinese food yesterday and now I'm paying for it on the toilet writing this review. I am down 13 pounds so far but i am also doing a calorie deficit and light workouts. I noticed dark orange blobs in the toilet that i assume would be fat. So yes they work. The first few days on it i was only eating salads and yogurt with no bowel movement changes until I ate fatty foods.

A top negative review is from a verified purchaser named KD gave the product a rating of 1/5:

If I could give this no stars I would. They make it seem like this is okay for you to take and so I got it. But after noticing weird side effects I did a deep dive search on these pills. Don’t not take this, it will make your period cycle irregular. I haven’t taken this for a long time but thankfully I stopped. I want a refund but my order is way past that point so I’m just going to throw these out. Not risking my health over these pills.

Other people also mentioned that since Alli went off the market in 2015 and re-emerged now, it’s not half as good as it was at the time.

Where to Find the Best Value

Alli is available for purchase at various retail stores. It is available on Amazon at the following prices:

• Starter pack (60 capsules) cost $ 47.88
• Refill pack (120 capsules) cost $ 72.99
• Refill pack (170 capsules) cost $ 86.99

Prices may vary depending on the retailer and package size.

At a surface glance, it looks as if Alli is relatively affordable than some other weight loss products. But, if you take Alli like you should (a capsule about 3 times a day) the 60-capsule bottle will not take you up to 30 days. This means the true cost of taking Alli per month is north of $70.

Compared to KetoFuse that costs only $47 for a full month supply (and as low as $35.4 when you buy in bulk), Alli is expensive.

Pros & Cons of Alli

Should You Buy Alli?

Alli has received mixed reviews from users. Some customers report steady weight loss when following a strict low-fat diet, while others experience minimal results or unpleasant digestive side effects. On Amazon, Alli holds a decent 4.1-star rating, but negative reviews often highlight side effects like oily stools and the need for strict dietary adjustments. Many users also mention that weight loss with Alli is slow and not as significant as expected.

While Alli’s active ingredient, Orlistat, is clinically proven to block fat absorption, it doesn’t boost metabolism or burn stored fat. This means weight loss results depend heavily on diet and consistency. Additionally, its side effects, including digestive discomfort and frequent bowel movements, can make long-term use challenging.

For those looking for a more effective and comprehensive weight loss approach, KetoFuse offers a better alternative. Unlike Alli, which only prevents fat absorption, KetoFuse includes proven metabolism-enhancing ingredients like Raspberry Ketones, Green Tea Extract, and African Mango to support fat burning, increase energy, and help with appetite control. This combination provides a more balanced and effective weight loss solution.

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Additionally, KetoFuse comes with a 60-day money-back guarantee, offering a risk-free way to achieve weight loss goals—something Alli does not provide. If you’re looking for a supplement that actively supports metabolism without unpleasant digestive side effects, KetoFuse delivers a smarter and more reliable option.